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Antibacterial and Immuno-Modulatory Roles of Ocimum Gratissimum in the Control of E. coli O157:H7 Chicken Colibacillosis

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Antibacterial and Immuno-Modulatory Roles of Ocimum Gratissimum in the Control of E. coli O157:H7 Chicken Colibacillosis


Ikele, O. M. | Ezeonu, I. M. | Umeoduagu, N. D.



Ikele, O. M. | Ezeonu, I. M. | Umeoduagu, N. D. "Antibacterial and Immuno-Modulatory Roles of Ocimum Gratissimum in the Control of E. coli O157:H7 Chicken Colibacillosis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-6, October 2022, pp.640-647, URL: https://www.ijtsrd.com/papers/ijtsrd51930.pdf

O. gratissimum is one of the leafy vegetables used by Nigerians as a food additive in preparing some local dishes. It has also been documented by some researchers to have some medicinal values. This research aimed at monitoring the immunomodulatory and antibacterial roles of Ocimum gratissimum ethanolic extract in the control of colibacillosis in broilers; as a natural alternative to antibiotic therapy.1.5 ml 107 cfu/ml E. coli O157:H7 isolated from nono (sour milk) and identified with 16s rDNA sequencing, was used to elicit colibacillosis infection in three weeks old broilers. Oral administration of the plant extract (40 g/l) to the infected birds over a 1 month period resulted in regulated haemoglobin, blood electrolytes, urea, creatinine, C-reactive protein and liver enzyme values. Microbial counts in the intestine revealed a decrease in total E. coli count. Histopathology examination of the intestinal tissues revealed the activity of gut associated lymphoid tissue in immune response. O. gratissimum ethanolic extract can serve as a natural alternative to antibiotic therapy in the control of colibacillosis in broilers.

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IJTSRD51930
Volume-6 | Issue-6, October 2022
640-647
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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